Impact of symptomatic upper respiratory tract infections on insulin absorption and action of Technosphere inhaled insulin
نویسندگان
چکیده
منابع مشابه
Impact of symptomatic upper respiratory tract infections on insulin absorption and action of Technosphere inhaled insulin
OBJECTIVE Uncomplicated, acute upper respiratory tract infections (URTIs) occur in patients with diabetes at a similar frequency to the general population. This study (NCT00642681) investigated the effect of URTIs on the pharmacokinetic (PK) and pharmacodynamic (PD) properties of Technosphere inhaled insulin (TI) in patients with type 1 or type 2 diabetes. RESEARCH DESIGN AND METHODS This was...
متن کاملInfluence of acute upper respiratory tract infection on the absorption of inhaled insulin using the AERx insulin Diabetes Management System.
AIMS To assess the effects due to an uncomplicated acute upper respiratory tract infection (URTI) on the pharmacokinetics and glucose response of insulin when delivered by oral pulmonary absorption. METHODS Normally healthy adult men (n = 11) and women (n = 9) received a single dose of inhaled human insulin, equivalent to approximately 6 IU subcutaneous, using the AERx insulin Diabetes Manage...
متن کاملTechnosphere Inhaled Insulin: Is Faster Better?
Pulmonary-delivered insulin is again a reality (1). The failure of the first inhaled insulin in 2007 showed that being radically different from what health care providers are used to, even when injections are avoided, can be problematic. The current product Technosphere inhaled insulin has addressed many of the prior concernsda more convenient delivery device that is dosed in insulin units. Als...
متن کاملPlace of technosphere inhaled insulin in treatment of diabetes
Technosphere insulin (TI), Afrezza, is a powder form of short-acting regular insulin taken by oral inhalation with meals. Action of TI peaks after approximately 40-60 min and lasts for 2-3 h. TI is slightly less effective than subcutaneous insulin aspart, with mean hemoglobin A1c (HbA1c) reduction of 0.21% and 0.4%, respectively. When compared with technosphere inhaled placebo, the decrease in ...
متن کاملUpper Respiratory Tract Infections
The upper respiratory system includes the nose, nasal cavity, pharynx, and larynx with subglottic area of trachea. In the normal circumstances, air enters the respiratory system through nostrils where it is filtered, humidified, and warmed inside the nasal cavity. Conditioned air passes through pharynx, larynx, and trachea and then enters in lower respiratory system. Dysfunction of any part of ...
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ژورنال
عنوان ژورنال: BMJ Open Diabetes Research & Care
سال: 2016
ISSN: 2052-4897
DOI: 10.1136/bmjdrc-2016-000228